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Dquality bovine embryos [23]. On the other hand, Min et al. (2014) reported that treatment during IVC with E-64 (0.1 and 0.5 M) significantly improves developmental rates without any noticeable effect on cleavage rate [24]. Unlike the former study which assessed role of cathepsin B inhibition during IVM, other research groups showed that addition of E-64 during in vitro culture (IVC) also improves

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